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ab18521  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology ab18521
    Ab18521, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 63 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    ab18521 - by Bioz Stars, 2026-06
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    ab18521  (Santa Cruz Biotechnology)
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. <t>Histone</t> <t>3</t> was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.
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    Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. Histone 3 was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.

    Journal: Scientific Reports

    Article Title: Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

    doi: 10.1038/s41598-024-70612-2

    Figure Lengend Snippet: Characterization of HGPS/hACE2 mice. ( A ) Schematic diagram of HGPS/hACE2 mouse generation strategy using mES editing combined with tetraploid complementation techniques. ( B ) Western blot analysis of lung tissues from hACE2 and HGPS/hACE2 mice, showing the presence of Lamin A/C in wild type lung and progerin in HGPS lungs. Histone 3 was used as a loading control. ( C ) Representative photographs of 2-month-old unedited, heterozygous, and homozygous Lmna c.1827C < T mutant hACE2 mice. ( D ) Survival curve plot showing the life span of wild type, heterozygous and homozygous Lmna mutant mice. D = days ( E ) Boxplots illustrating the body weight distribution among young, aged, and HGPS Balb/c mice. ( F ) Volcano plot showing transcriptome changes in the lungs between hACE2 and HGPS/hACE2 mice. Significantly differentially expressed genes are highlighted in green (upregulated in HGPS) and red (upregulated in wild type). ( G ) Dropblot of GO analysis results derived from differentially expressed gene sets in the lungs of 2-month-old hACE2 and HGPS/hACE2 mice.

    Article Snippet: The following primary antibodies were used: anti-LAMINA/C (CST, 4777S, 1:1000), anti-progerin (abcam, ab66587, 1:1000), Histone 3 (abcam, ab18521, 1:5000).

    Techniques: Western Blot, Control, Mutagenesis, Derivative Assay